Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome.
BACKGROUND: Propofol is commonly used as sedative in newborns and children.Recent experimental studies led to contradictory results, revealing neurodegenerative or neuroprotective properties of propofol on the developing brain.We investigated neurodevelopmental short- and long-term effects of neonatal propofol treatment.METHODS: 6-day-old Wistar ra